(MedPage Today) -- The average age at onset of diffuse large B-cell lymphoma (DLBCL) is about 65 years, and a significant proportion of patients will be 80 or older and frail or unfit.
While chronologic age and tests to determine fitness or frailty...
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-
Safe and Effective Therapies for Unfit Elderly Patients With DLBCL
via medpagetoday.com -
Epic Fail: Robots Don't Improve Joint Replacement Outcomes in Big U.K. Studies
via medpagetoday.com(MedPage Today) -- Robotically assisted knee and hip arthroplasties have brought no extra benefits for patients in Great Britain compared with conventional procedures, a massive review of registry data showed.
Revision rates over the first 5 years... -
New Easier-to-Use GLP-1 Pill Safe for the Heart, Study Says
via medpagetoday.com(MedPage Today) -- Orforglipron (Foundayo) was able to claim cardiovascular safety based on the ACHIEVE-4 trial, though heart benefits remain unproven.
Among adults with type 2 diabetes and obesity or overweight at risk for increased cardiovascular... -
SERD Combination Slows Breast Cancer After CDK4/6 Inhibitor Progression
via medpagetoday.com(MedPage Today) -- An all-oral treatment regimen for advanced estrogen receptor (ER)-positive breast cancer almost doubled progression-free survival (PFS) versus standard endocrine therapy in a study of post-CDK4/6 progression disease.
Among patients... -
Who Should Manage a Hospital Cyberattack?
via medpagetoday.com(MedPage Today) -- The malware attack was over. It was the only thing anyone could talk about during my weekend shift at a midsize hospital. Our hospital had spent the last 3 weeks relying on paper charts and written orders, but Epic was finally... -
Unexpected Lack of Survival Benefit in Liver Cancer Treated With Proton Therapy
via medpagetoday.com(MedPage Today) -- Proton therapy failed to improve survival in locally advanced hepatocellular carcinoma (HCC) compared with photons, surprising investigators in the multicenter randomized NRG-GI003 trial.
Patients treated with photon radiation... -
Senate Committee Advances Surgeon General Nominee
via medpagetoday.com(MedPage Today) -- Nicole Saphier, MD, President Donald Trump's third nominee for surgeon general, moved a step closer to confirmation after a Senate committee voted to advance her nomination on Wednesday.
Saphier, a radiologist and former Fox... -
No Clear Risks With GLP-1s Around Pregnancy, but Caution Urged
via medpagetoday.com(MedPage Today) -- Use of GLP-1 receptor agonists around pregnancy did not appear to increase adverse maternal or perinatal outcomes, according to two studies.
In a systematic review and meta-analysis of 10 studies representing over 2.1 million... -
These Specialties Had the Highest Starting Salaries This Year
via medpagetoday.com(MedPage Today) -- Most physician specialties had an increase in average starting salary from last year, according to AMN Healthcare's 2026 report on recruiting incentives.
Gastroenterology had the highest average starting salary this year at... -
VA's New Antidepressant Rules; App Aids Schizophrenia; Diet and Depression
via medpagetoday.com(MedPage Today) -- A new Veterans Affairs policy for younger veterans will require signed consent forms and documented discussions about antidepressant risks and benefits before receiving a prescription. (New York Times)
Meanwhile, eight sailors... -
Sepsis in Pregnancy Is a Deadly Combo: Here's Who's at Risk
via medpagetoday.com(MedPage Today) -- While rare, sepsis in pregnancy was nevertheless involved in nearly a third of maternal deaths in Mississippi, a state with one of the highest maternal mortality rates, and women with certain characteristics were particularly... -
Treatment Strategies for Richter's Transformation to DLBCL Are Evolving
via medpagetoday.com(MedPage Today) -- Richter's transformation (RT) occurs when chronic lymphocytic leukemia (CLL) changes into an aggressive lymphoma.
Approximately 2% to 10% of patients with CLL progress to RT within a median time of 2 to 4 years from diagnosis... -
Poll: Rural MAHA Followers Say Trump Hasn't Improved Health of Their Communities
via medpagetoday.com(MedPage Today) -- About half of rural voters identify with Make America Healthy Again (MAHA), a sprawling political movement championed by the Trump administration, but most said President Donald Trump's healthcare policies have not benefited... -
National care service may not launch until late 2030s, suggests Burnham
via ft.comPrime minister admits scrapping pensions triple lock will not fund social care reforms until later next decade -
CDC Raises Measles Death Count Again; MAHA Summit Takeaways; Kennedy's Vax AI Plans
via medpagetoday.com(MedPage Today) -- The CDC has updated its measles death tally to two, but it remains shy of the four deaths reported by Pennsylvania. (The Hill)
The agency has lost more employees during the second Trump administration than previously reported... -
CAR-T Therapy Shows Durable Benefits in Myasthenia Gravis
via medpagetoday.com(MedPage Today) -- Mivocabtagene autoleucel (miv-cel), an autologous CD19 chimeric antigen receptor (CAR)-T cell therapy, showed benefits lasting 6 months or longer for generalized myasthenia gravis patients in the phase II portion of the KYSA... -
Why Earlier Conversations About Long-Acting Injectables for Schizophrenia Matter
via medpagetoday.com(MedPage Today) -- Bryce Reynolds, MD, at Carolina Outreach is a paid partner of Teva Pharmaceuticals.
One of the biggest paradoxes in schizophrenia care is that some of our most established treatment options are still among the least utilized... -
RFK Jr. Dumps on U.S. Doctors; New Chief at PhRMA; Physician Wins 'Genius' Grant
via medpagetoday.com(MedPage Today) -- Note that some links may require registration or subscription.
HHS Secretary Robert F. Kennedy Jr. said artificial intelligence is "much better informed than any doctor in the country." (New York Times)
Meanwhile, only about... -
Social care shake-up without tax rises will force houses to be sold, Burnham warned
via ft.comExpert says comprehensive model for England in which all costs were covered would be £18.7bn -
National care service could not launch until late 2030s, suggests Burnham
via ft.comPrime minister admits scrapping pensions triple lock will not fund social care reforms until later next decade -
Is AI Coming to the Medicare Annual Wellness Visit?
via medpagetoday.com(MedPage Today) -- Should Medicare's annual wellness visit (AWV) be less physician-driven and more artificial intelligence (AI)-driven?
That's the question being asked by CMS in its proposed physician payment rule, issued this past summer.
Although... -
Lindsay Clancy's Lawyer Now Questions Whether She Killed Her 3 Children
via medpagetoday.com(MedPage Today) -- Lindsay Clancy's lawyer argued Tuesday that there wasn't enough evidence to prove she killed her three children, a striking turn after a lengthy trial that focused more on her mental state than on whether she took their lives... -
Fractionated SRS Improves Local Control After Brain Metastasis Resection
via medpagetoday.com(MedPage Today) -- Local control after surgical removal of large brain metastases improved significantly when patients received fractionated stereotactic radiosurgery (SRS) instead of single-fraction SRS, a randomized trial showed.
Surgical-bed... -
Trump Administration Suppressed USPSTF Recommendations, Past Chair Says
via medpagetoday.com(MedPage Today) -- Leadership of the agency that oversees the U.S. Preventive Services Task Force (USPSTF) suppressed the group's recommendations, a former task force chair said.
The director of the Agency for Research Healthcare and Quality ... -
Trump Administration Suppressed USPSTF Recommendations
via medpagetoday.com(MedPage Today) -- Leadership of the agency that oversees the U.S. Preventive Services Task Force (USPSTF) suppressed the group's recommendations, a former task force chair said.
The director of the Agency for Research Healthcare and Quality ... -
Doctor Describes 'Liberating' Experience of Walking Off the Job
via medpagetoday.com(MedPage Today) -- Physicians at Allina Health in Minnesota reached a tentative agreement following a 4-day strike on their first union contract, which still awaits ratification. The proposed contract includes protections intended to allow physicians... -
Alcohol and the Brain; The Next Alzheimer's Frontier; Mice With Human Brain Cells
via medpagetoday.com(MedPage Today) -- The New York Times looked at what alcohol does to the brain and what amount, if any, may be safe.
Ongoing phase I/II studies of ifezuntirgene inilparvovec (AMT-130) in Huntington's disease showed continued slowing of disease... -
Battle Over Cardiologist Non-Competes; Declines Well Before CVD; GLP-1s and Stroke
via medpagetoday.com(MedPage Today) -- In upstate New York, patients risk losing care as Ellis Medicine and St. Peter's Health Partners battle in court over the non-compete agreements of 27 cardiologists. (CBS6)
American guidelines were updated regarding perioperative... -
FDA Approves First Treatment for Rare Thyroid Hormone Disorder
via medpagetoday.com(MedPage Today) -- The FDA approved tiratricol (Emcitate) to treat peripheral thyrotoxicosis in patients with monocarboxylate transporter 8 (MCT8) deficiency, the agency announced on Monday, marking the first approval for this rare genetic disorder... -
Thyroid Drug Recall Most Serious; GLP-1s and Vitamin Deficiency; New T1D Guidelines
via medpagetoday.com(MedPage Today) -- The FDA designated Vitruvias Therapeutics' recall of a lot of 30-mg levothyroxine-liothyronine tablets (Thyroid Tablets) as Class I, its most serious classification. (USA Today)
At least six major U.S. hospitals have shut down...
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