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Patient Death Reported in Multiple Sclerosis CAR-T Study
(MedPage Today) -- The investigational CD19-directed chimeric antigen receptor (CAR) T-cell therapy zolacabtagene autoleucel (zola-cel) showed the potential to treat people with highly active relapsing multiple sclerosis (MS) and progressive MS...
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Butter Recalled in 10 States; Voters Worry Over Healthcare; New Organ Donation Rules
(MedPage Today) -- Note that some links may require registration or subscription.
Plant-based butter made by Miyoko's Creamery has been recalled in 10 states over concerns for yeast, mold, and E. coli contamination. (ABC News)
Meanwhile, a popular...
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Injections for Achilles Tendinopathy Flop in Randomized Trial
(MedPage Today) -- High-volume injections to relieve pain and disability for patients with Achilles tendinopathy failed to demonstrate significant benefit versus sham injections in a randomized trial.
With 192 patients assigned to three arms ...
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Rare Brain Disorder Linked to Water Pollution Sources
(MedPage Today) -- People living near industrial facilities that polluted the water supply were more likely to develop progressive supranuclear palsy (PSP), a rare and severe neurodegenerative tauopathy, a study of U.K. Biobank participants showed...
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RFK Jr. Eases Access to Unproven Peptides Despite Opposition From FDA Scientists
(MedPage Today) -- The Trump administration on Wednesday acted to ease access to unproven peptide drugs favored by Health Secretary Robert F. Kennedy Jr., and FDA scientific staffers had little input on the decision and opposed the changes, according...
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Another Win for Novel Drug, This Time in EGFR-Mutated Lung Cancer
(MedPage Today) -- A first-in-class bispecific antibody-drug conjugate (ADC) nearly doubled progression-free survival (PFS) compared with chemotherapy in patients with EGFR-mutated advanced non-small cell lung cancer (NSCLC) who progressed on third...
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Couples Achieved Live Births Faster With IVF First
(MedPage Today) -- BALTIMORE--Couples who bypassed intrauterine insemination (IUI) and went straight to in vitro fertilization (IVF) achieved a live birth faster, a multicenter randomized controlled trial in Australia showed.
At 7 months...
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For Select AV Blocks, Trial Gives Win to Pacemakers With LBBA Pacing
(MedPage Today) -- For lower-risk patients with atrioventricular block (AVB) requiring substantial ventricular pacing, left bundle branch area pacing (LBBAP) was able to claim superiority in a randomized trial from China.
Among such individuals...
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Review: 'You Can See Everything' Trains Its Lens on Elizabeth Holmes of Theranos
(MedPage Today) -- Thirty-four days before the disgraced Theranos founder Elizabeth Holmes was due in federal prison to serve an 11-year sentence for conspiracy and fraud, she and her partner, Billy Evans, welcomed a film crew into their beachside...
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Managing Hidradenitis Suppurativa in Skin of Color
(MedPage Today) -- Hidradenitis suppurativa (HS) disproportionately affects Black patients, who may experience more severe disease, longer diagnostic delays, and greater healthcare utilization, according to Julia M. Riley, MD, of Northwestern University...
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Christopher Lloyd's Addictions; Antipsychotics and Cancer; Detransition Clinic Opens
(MedPage Today) -- Actor Christopher Lloyd, 88, opened up about his struggles with addiction to cocaine, alcohol, and marijuana during the 1970s and 1980s. (USA Today)
Health Secretary Robert F. Kennedy Jr. reportedly plans to bypass a candidate...
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My Patients Used to Ask for the Doctor in the Hawaiian Shirt
(MedPage Today) -- "Can you get the doctor with the Hawaiian shirt back? We have a question. We'd like to see him."
A family said this to a nurse in my intensive care unit (ICU). They had met a parade of physicians that day, and there was no doubt...
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RFK Jr.'s Future With Trump; 'Metabolic Psychiatry' Appointee; Kratom Ban Backtrack
(MedPage Today) -- There are "zero" signs that HHS Secretary Robert F. Kennedy Jr. will leave the Trump administration after the midterms. (Axios)
Kennedy is reportedly considering Shebani Sethi, MD, a psychiatrist who coined the term "metabolic...
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Study Warns on Immunotherapy De-Escalation in Advanced Cancers
(MedPage Today) -- For patients with advanced or metastatic solid tumors who had initial responses to immune checkpoint inhibitors (ICIs), reducing dose intensity did not preserve efficacy, an interim analysis of the MOIO study suggested.
For...
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ADC Scores 'Impressive' Survival Win in Heavily Pretreated Gastroesophageal Cancer
(MedPage Today) -- Overall survival (OS) in heavily pretreated gastroesophageal carcinoma (GEC) doubled in patients who received an investigational antibody-drug conjugate (ADC) targeting claudin (CLDN) 18.2, a randomized trial showed.
Patients...
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ChatGPT Linked to Death; FDA Flags Cancer Drug Claims; AMA Fights Medicaid Rules
(MedPage Today) -- Note that some links may require registration or subscription.
The parents of a 31-year-old software engineer with epilepsy who died in February sued OpenAI, claiming ChatGPT told the engineer to stop taking her seizure medication...
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Congress Mulls Ways to Fix the Surprise Billing Law
(MedPage Today) -- Although most observers agree that the No Surprises Act did fix one problem--nixing unexpected bills for out-of-network care--lawmakers are still trying to fix other problems caused by the law.
The act, passed at the...
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Fenebrutinib May Curb Chronic Active Lesions in Multiple Sclerosis
(MedPage Today) -- The investigational Bruton's tyrosine kinase (BTK) inhibitor fenebrutinib may curb chronic active lesions in multiple sclerosis (MS), data from phase III trials suggested.
Two MRI biomarkers in MS are slowly expanding lesions...
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Lyme Disease Vaccine Candidate Just Misses Its Mark in Late-Stage Trial
(MedPage Today) -- WASHINGTON--An investigational Lyme disease vaccine covering six serotypes across four Borrelia species had a vaccine efficacy (VE) rate of over 70%, but it just missed a preset noninferiority threshold, a placebo-controlled...
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AI May Help Detect Rare Sperm in Men With Azoospermia
(MedPage Today) -- BALTIMORE--An artificial intelligence (AI)-powered tool could be a last resort for couples wanting to conceive a biological child who had been told they have no sperm, researchers said.
The Sperm Tracking and Recovery (STAR...
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RFK Jr.'s Claim That Arabs 'Don't Produce Science' Meets a Nobel Prize Reality Check
(MedPage Today) -- Health and Human Services (HHS) Secretary Robert F. Kennedy Jr.'s broad assertions about Arab contributions to humanity's scientific and literary discoveries at a Republican campaign event in Grand Rapids, Michigan, have drawn...
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Novel HDAC Inhibitor Hits Main Goal in Unresectable Melanoma Trial
(MedPage Today) -- Progression-free survival (PFS) in unresectable melanoma improved significantly with the addition of an investigational histone deacetylase (HDAC) inhibitor to immunotherapy, a randomized trial showed.
Median PFS increased from...
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Certain Myasthenia Gravis Patients May Need More Time to Respond to Efgartigimod
(MedPage Today) -- Intravenous efgartigimod (Vyvgart) continued to show efficacy and safety in patients with generalized myasthenia gravis who did not have detectable anti-acetylcholine receptor (AChR) antibodies, according to open-label data from...
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Bid to Block GLP-1 Ads Denied; First Weekly Insulin for T2D in Kids; Fertility Fell
(MedPage Today) -- A U.S. judge rejected Novo Nordisk's request to temporarily block Eli Lilly from running advertisements claiming its weight-loss and diabetes drugs are more powerful. (Reuters via AOL)
The FDA expanded the approval for insulin...
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Head Shape and Alzheimer's; Prenatal Choline and Kids' IQ; Aspirin and Dementia
(MedPage Today) -- Can head shape influence Alzheimer's disease pathology? (Alzheimer's & Dementia)
The newly launched AD-Smart Alzheimer's disease platform trial will test repurposed drugs in the U.K., starting with the diabetes drug metformin...
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Live Webinar October 29: Should We Let Robots Be Doctors?
(MedPage Today) -- While some major medical organizations like the American Medical Association (AMA) have adopted policies relegating artificial intelligence (AI) to an assistive rather than autonomous role in healthcare, bioethicist and oncologist...
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Cardiologist-Prime Minister? LDL Pill Eyed for Diabetes; Second Tricuspid TEER OK'd
(MedPage Today) -- Cardiologist Ilija Srdanović, MD, PhD, is among the student-backed leaders in Serbia that won the country's snap parliamentary election. Some expect him to be the new prime minister. (Nacionale)
The CETP inhibitor obicetrapib...
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Trial Results Show 'Something We Have Not Seen for Years' in Osteosarcoma
(MedPage Today) -- The investigational antibody-drug conjugate (ADC) risvutatug rezetecan (Ris-Rez) significantly improved progression-free survival (PFS) in patients with relapsed or refractory osteosarcoma, the phase III ARTEMIS-011 trial from...
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ADA Says Protest 'Threat' Heightened Security Concerns at Meeting
(MedPage Today) -- In a reversal of its original findings, the American Diabetes Association (ADA) said members who were kicked out of its annual meeting in June did not violate its code of conduct.
Instead, the final report of its governance...
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Elizabeth Holmes: Master of Deception or Victim of Coercion?
(MedPage Today) -- I wasn't planning to see Nathan Fielder and Lance Oppenheim's movie about Elizabeth Holmes, "You Can See Everything." What truth would I learn? Holmes has every reason to try to rehabilitate her image, and I'm used to working...
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