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-
I Was an NIH Program Official. Here's What a Peer Reviewer Doesn’t See.
via medpagetoday.com(MedPage Today) -- In a June 18 opinion piece in MedPage Today, Anthony LoSasso, PhD, a health economist who served on NIH study sections for 12 years, took issue with a recent New England Journal of Medicine (NEJM) editorial that criticizes the... -
Long-Term CAR-T Results in Lymphoma Confirm Early Promise
via medpagetoday.com(MedPage Today) -- Ten years after receiving a single dose of CD19-targeted CAR T-cell therapy, almost a third of patients with aggressive lymphomas and no treatment options remained lymphoma free, updated results from a landmark trial showed... -
ALS Testing Expected to Drive Sharp Rise in Clinic Visits
via medpagetoday.com(MedPage Today) -- Genetic testing of people with a family member diagnosed with amyotrophic lateral sclerosis (ALS) will greatly increase the number of clinic visits to specialized ALS centers over the next decade, a population model showed.... -
Midterm TAVR Data Turn Muddy: Will 10 Years Even Suffice for a Verdict?
via medpagetoday.com(MedPage Today) -- NEW YORK CITY--It was increasingly clear that clinical trials alone won't tell the full story of how transcatheter aortic valve replacement (TAVR) performs in the real world, according to midterm studies presented here.... -
Health Spending Projected to Hit Almost $9 Trillion in 2034
via medpagetoday.com(MedPage Today) -- Health expenditures are expected to reach $8.97 trillion by 2034, while the percentage of the population with health insurance is expected to decline for the next several years, said researchers at the Centers for Medicare &... -
Few IVF Add-Ons Have Any Proven Benefits, Study Shows
via medpagetoday.com(MedPage Today) -- Many popular in-vitro fertilization (IVF) add-ons have little proven benefit, but an evidence-based website helped patients better understand the treatments so they could make an informed decision, a pair of companion studies... -
South African Civil Groups Warn of Dire Impact as U.S. Phases Out HIV Funding
via medpagetoday.com(MedPage Today) -- Civil society organizations in South Africa said Wednesday that adolescent girls and women are among the first vulnerable groups to feel the pinch of U.S. foreign aid cuts as the Trump administration phases out its more than... -
Shorter TB Regimen Matched Standard Care in Rifampicin-Resistant Disease
via medpagetoday.com(MedPage Today) -- A 6-month tuberculosis (TB) treatment regimen delivered similar results to the longer standard-of-care regimen in patients with pulmonary rifampicin-resistant TB, a phase III noninferiority trial showed.
Among 402 patients... -
FDA Approves CDK4/6 Inhibitor for HER2-Positive Breast Cancer
via medpagetoday.com(MedPage Today) -- The FDA approved the CDK4/6 inhibitor palbociclib (Ibrance) as part of a first-line maintenance regimen for hormone receptor (HR)-positive/HER2-positive breast cancer.
Approval stipulates use of palbociclib plus trastuzumab... -
Can Advanced MRI Personalize Radiation for Glioblastoma?
via medpagetoday.com(MedPage Today) -- Following the American Society of Neuroradiology (ASNR) meeting, MedPage Today convened three leaders in neuro-oncology and brain tumor imaging for a virtual roundtable discussion on the evolving role of advanced MRI in brain... -
Severe Hypertriglyceridemia Drug Approved to Reduce Triglycerides, Pancreatitis Risk
via medpagetoday.com(MedPage Today) -- The FDA approved olezarsen (Tryngolza) to reduce triglycerides and the risk of acute pancreatitis in adults with severe hypertriglyceridemia, the agency announced on Wednesday.
Olezarsen, an mRNA-targeted antisense oligonucleotide... -
Nature Retracts Cancer Study Suggesting Treatment Is Better Earlier in the Day
via medpagetoday.com(MedPage Today) -- After a 4-month investigation, Nature Medicine retracted a study that showed that the time of day in which immunochemotherapy was given for non-small cell lung cancer (NSCLC) had an effect on survival outcomes.
In the phase... -
Nature Retracts Cancer Study Linking Treatment Timing to Survival
via medpagetoday.com(MedPage Today) -- After a 4-month investigation, Nature Medicine retracted a study that showed that the time of day in which immunochemotherapy was given for non-small cell lung cancer (NSCLC) had an effect on survival outcomes.
In the phase... -
How a Drug With More Negative Than Positive Studies Won FDA Approval
via medpagetoday.com(MedPage Today) -- The FDA should require negative studies of a new drug to be included in the product's labeling--not just those studies with a beneficial finding--to prevent physicians and consumers from being misled about the drug's... -
LSD's Depression Win; Summer Heat and Suicide; Antipsychotic Nonresponse Predictors
via medpagetoday.com(MedPage Today) -- Topline data showed that a single dose of an investigational LSD-based pill (DT120) met primary and key secondary endpoints in a phase III trial of adults with major depressive disorder, developer Definium Therapeutics said... -
Could TILs Serve as a Marker of Immunotherapy Benefit in Early TNBC?
via medpagetoday.com(MedPage Today) -- At the American Society of Clinical Oncology (ASCO) meeting, long-term follow-up from the KEYNOTE-522 trial reinforced the survival benefit of pembrolizumab (Keytruda)-based therapy in early-stage triple-negative breast cancer... -
Prenatal Exposure to Acid Suppressants and Kids' IBD Risk: No Need to Worry?
via medpagetoday.com(MedPage Today) -- Prenatal exposure to acid-suppressive drugs did not have a clear association with the development of inflammatory bowel disease (IBD) in childhood, a South Korean cohort study suggested.
While prenatal exposure to acid-suppressive... -
Are People With Eating Disorders Misusing GLP-1 Drugs?
via medpagetoday.com(MedPage Today) -- Use and misuse of GLP-1 receptor agonists were common in people with eating disorders, interim results of an ongoing cross-sectional study suggested.
Among over 400 people with eating disorders, 32.1% said they have used GLP... -
RFK Jr.'s Vax Agenda Lives; Filler 'Smuggling' Accusations; Peptide Gray Market
via medpagetoday.com(MedPage Today) -- Despite political warnings and legal challenges, there's still a push to keep HHS Secretary Robert F. Kennedy Jr.'s vaccine agenda alive--but it has shifted largely out of public view. Kennedy allies are "embedding his agenda... -
Judge Rules Government Can't Stop SNAP Dollars From Buying Candy and Sugary Drinks
via medpagetoday.com(MedPage Today) -- The federal government can't block benefits from the nation's largest food aid program from being used to buy candy, soda, and other sugary drinks, a judge ruled.
Monday's ruling scuttles restrictions now in place or planned... -
Fauci Subpoenaed; Army, Navy Reinstate Flu Shot Requirement; Milder Ebola Symptoms?
via medpagetoday.com(MedPage Today) -- Note that some links may require registration or subscription.
Sen. Rand Paul (R-Ky.) subpoenaed Anthony Fauci, MD, to appear before the Committee on Homeland Security & Governmental Affairs next month. (The Hill)
A bipartisan... -
Systemic maternity failures led to hundreds of deaths and injuries, review finds
via ft.comDamning report into Nottingham NHS trust criticises culture of bullying and staff ignoring pregnant women -
Higher Daytime Light Exposure Linked to Lower Dementia Risk
via medpagetoday.com(MedPage Today) -- People exposed to higher levels of daytime light had a lower risk of dementia, prospective data from 88,000 U.K. Biobank participants showed.
Over 8 years of follow-up, people who had an average daytime light exposure above... -
JAMA Journal Publishes COVID Vaccine Study Squelched by CDC Leader
via medpagetoday.com(MedPage Today) -- The COVID vaccine study that was suppressed by the acting CDC director earlier this year has now been published in a JAMA journal.
The case-control study showed that the estimated vaccine effectiveness (VE) rate during the 2025... -
New Strategies and Platforms for Gastroesophageal Cancer
via medpagetoday.com(MedPage Today) -- Improved understanding of the tumor microenvironment and genomics has fueled a new generation of therapies that could lead to better outcomes for esophageal cancer.
Some of those therapies have already made the leap from research... -
Evolution of Perioperative Immunotherapy in Resectable Esophageal Cancer
via medpagetoday.com(MedPage Today) -- The emergence of immunotherapy for esophageal cancer provided a glimmer of hope to patients and clinicians affected by the historically poor-prognosis disease. The glimmer has not only persisted but perhaps grown brighter as... -
Hundreds of Physicians, Other Clinicians at Banner Health File to Unionize
via medpagetoday.com(MedPage Today) -- More than 240 physicians and advanced practice providers from dozens of Banner Health locations throughout the Phoenix area have filed to unionize.
The effort comes as clinicians have expressed concerns about patient panel sizes... -
White House Denies Trump Got Unapproved Obesity Drug
via medpagetoday.com(MedPage Today) -- The White House aggressively denied a report that implied President Trump may have received the investigational obesity medication retatrutide.
STAT on Tuesday reported that Eli Lilly and the FDA granted one request for compassionate... -
Quarantine Comes to an End for Last Hantavirus Ship Passengers in Nebraska
via medpagetoday.com(MedPage Today) -- OMAHA, Nebraska--The last eight American passengers who endured 42 days in a specialized hospital quarantine unit after exposure to an unusual hantavirus outbreak on a cruise ship that killed three people have left the Nebraska... -
FDA Greenlights Generic Rifapentine for Tuberculosis
via medpagetoday.com(MedPage Today) -- The FDA approved the first generic version of rifapentine (Priftin) to treat active pulmonary tuberculosis (TB) in adolescents and adults, as well as latent TB infection in patients as young as 2 years.
The generic rifamycin...
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