(MedPage Today) -- The regulatory status of a low-dose atropine eye drop formulation for myopia remained unresolved following a day-long FDA advisory committee meeting, but closing comments did not bode well for SYD-101.
The Dermatologic and Ophthalmic...
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FDA Panel Largely Pans Trial Data for Myopia Eye Drops
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CVS break-up shows how M&A-first strategy is not the healthiest option
via HealthcareDespite touting better customer outcomes as well as major financial benefits, its stock price has underperformed
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Smartwatch Detection of Reduced LVEF? Not So Fast, Study Says.
(MedPage Today) -- The enthusiasm for smartwatch detection of left ventricular systolic dysfunction (LVSD) was tempered by a Korean study indicating difficulties with the technology in its current state.
Using an artificial intelligence (AI)-ECG...
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Common Antibiotic Tied to Pregnancy Loss Risk
(MedPage Today) -- Women exposed to doxycycline in early pregnancy had an increased risk of pregnancy loss compared to other antibiotics, a cohort study showed.
Doxycycline use for respiratory tract infection was linked with increased pregnancy...
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Police Investigate After 25 Half-Marathon Runners Seek Medical Care
(MedPage Today) -- Police in California are investigating after at least two dozen participants in the Santa Barbara Half Marathon ended up at the hospital on Sunday.
The Santa Barbara Police Department said in a statement it opened an investigation...
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Early Response to MASH Drug Linked to Resolution, Fibrosis Improvement
(MedPage Today) -- In patients treated with resmetirom (Rezdiffra), early responses in blood and imaging biomarkers were associated with resolution of metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis improvement, according to...
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Feud Between Former Trump Officials Exposes Divisions Over MAHA Movement
(MedPage Today) -- A public spat between former Trump administration officials over alleged corruption in public health policymaking is the latest front in Republicans' postelection recriminations, a battle that has exposed fault lines within the...
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Autism Risk Myths: 1 in 4 Adults Cite Vaccines or Tylenol
(MedPage Today) -- About one in four U.S. adults endorsed childhood vaccinations or acetaminophen (Tylenol) use during pregnancy as an autism risk factor, a cross-sectional study showed.
In a nationwide survey of 30,000 adults, 26.6% endorsed...
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M1/M4 Agonist Relieved Schizophrenia Symptoms in Mid-Stage Trial
(MedPage Today) -- ML-007C-MA, an investigational muscarinic M1/M4 receptor agonist that combines betovumeline and fesoterodine fumarate, significantly improved schizophrenia symptoms in adults who had an acute exacerbation of psychosis, data from...
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Trial Stopped Early for Superiority of LBBP-Tuned Pacemakers
(MedPage Today) -- Left bundle branch pacing (LBBP) drastically reduced clinical events among patients with atrioventricular (AV) block, with results good enough to stop the OptimPacing trial early.
In that international randomized trial of patients...
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Safety of Controversial Vasculitis Drug Bolstered in Dedicated Trial
(MedPage Today) -- ORLANDO--Interim results from a prospective trial designed to evaluate safety of avacopan (Tavneos), the embattled drug for antineutrophil cytoplasmic antibody-associated vasculitis (AAV), indicated that the product could...
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Valbenazine for Tardive Dyskinesia Tied to Less Antipsychotic Drop-Off
(MedPage Today) -- Starting valbenazine (Ingrezza) to treat tardive dyskinesia might reduce antipsychotic discontinuation in patients newly diagnosed with the side effect, a retrospective cohort study of Medicare claims indicated.
Among patients...
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Intensive Blood Pressure Control Gets a Win in Stroke Survivors
(MedPage Today) -- Two large trials conducted in Brazil in different patient populations came to somewhat divergent conclusions on the cardiovascular benefits of intensive blood pressure (BP) lowering.
Over roughly 4 years of median follow-up...
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Why Not Sirolimus for Active Lupus?
(MedPage Today) -- ORLANDO--Patients with systemic lupus erythematosus (SLE) that is uncontrolled despite standard therapy did well with a daily oral dose of sirolimus in a trial from China, although safety concerns weren't entirely relieved...
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Bulevirtide Linked to Less Decompensation in Chronic Hep D With Cirrhosis
(MedPage Today) -- In patients with chronic hepatitis delta (CHD) with cirrhosis, treatment with bulevirtide (Hepcludex) was associated with lower risk of liver decompensation, according to results from a European retrospective study.
Among more...
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The Flu Shots Are Here! The Flu Shots Are Here!
(MedPage Today) -- Every year, we wait on the arrival of this season's annual flu vaccine, patiently biding our time and explaining to our patients that it's coming, any day now, while the manufacturers finish their processes of selecting the candidate...
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Was Superglue to Blame for His Lung Nodule?
(MedPage Today) -- A CT scan turned up an incidental nodule in the lung of a patient being evaluated for kidney stones, and clinicians' best guess is that it had something to do with superglue.
The patient, a man in his 40s, presented to an emergency...
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FDA Slaps New Safety Warning on GLP-1 Drugs
(MedPage Today) -- The FDA is requiring manufacturers of all GLP-1 drugs to update their prescribing information to include a warning about the potential risk of non-arteritic anterior ischemic optic neuropathy (NAION), a rare but potentially blinding...
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FBI Investigates Doc's Death; Measles Cases Top 5,000; Can Flu Shot Fight Cancer?
(MedPage Today) -- Note that some links may require registration or subscription.
The FBI is aiding in an investigation over the death of Heather Kovich, MD, a prominent family medicine physician in New Mexico who died last month on the Navajo...
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Trial Finds Tangible Results From Yoga as Cardiac Rehab
(MedPage Today) -- Yoga-based cardiac rehabilitation did not change cardiac outcomes for people with heart failure and reduced ejection fraction (HFrEF), though there were big boosts in exercise capacity and quality of life in an Indian randomized...
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What Do Patients With Sleep Disorder Really Mean by 'Brain Fog'?
(MedPage Today) -- Brain fog among individuals with sleep disorders was primarily characterized by memory impairment, difficulty concentrating, and forgetfulness, according to a lexicon analysis of social media posts.
Among 554,312 posts and comments...
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'They Don’t Know the Questions to Ask': What We Heard This Week
(MedPage Today) -- "They have the best of intentions and want to help, but they don't know the questions to ask."--Anthea Gray, PsyD, of the Ohio State University Comprehensive Cancer Center in Columbus, discussing the first guidelines for...
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Triple-Target Incretin Drug Kills Knee Osteoarthritis Pain in Obesity
(MedPage Today) -- ORLANDO--The investigational obesity drug retatrutide was highly effective in reducing pain and improving disability in knee osteoarthritis (OA) associated with obesity, according to the TRIUMPH-4 trial.
Among patients in...
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Adjunctive L-Methylfolate Tied to Executive Function Gains in Psychiatric Patients
(MedPage Today) -- In treatment-experienced psychiatric patients receiving established pharmacotherapy, adjunctive L-methylfolate (Deplin) was linked with significant reductions in overall symptom burden and improvements in executive function...
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Lost in the Labyrinth of Nicotine Products
(MedPage Today) -- Americans increasingly navigate a fast-changing marketplace of nicotine and tobacco products. Walk into a convenience store today and you will encounter a dizzying array of products: cigarettes, e-cigarettes, nicotine pouches...
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Student Loan Limits for PAs, Other Health Workers Steering Many to Private Lenders
(MedPage Today) -- New limits on federal student loans filled Chloe Frabotta with anxiety as she began studying in New York City to become a physician assistant.
The changes that took effect this fall include caps on loans for particular programs...
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Ditching Primary Prevention Statins in Old Age? Technically 'Safe' With Caveats
(MedPage Today) -- Long-time statin users over age 70 were arguably fine stopping therapy in the STREAM randomized trial, but the results hardly boded well for longer-term cardiovascular safety, and there was no upside in quality of life.
A strategy...
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Ziltivekimab Falls Short for Cutting Cardiovascular Events in ASCVD, CKD
(MedPage Today) -- Despite lowering inflammatory markers, treatment with the monoclonal antibody ziltivekimab did not reduce cardiovascular events in patients with atherosclerotic cardiovascular disease (ASCVD), chronic kidney disease (CKD), and...
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Oral LSD Drug Hits Phase III Endpoints in Anxiety, Depression
(MedPage Today) -- DT120, an investigational orally disintegrating tablet (ODT) formulation of the psychedelic lysergide (LSD), met the primary endpoints in a pair of phase III trials for generalized anxiety disorder (GAD) and major depressive...
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Avoiding Chemo in Breast Cancer; Psychedelic Medication for Depression
(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of Texas Tech Health El Paso, look at the top medical...
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