(MedPage Today) -- Novel in vivo CRISPR-based therapy lonvoguran ziclumeran (lonvo-z) dramatically lowered hereditary angioedema (HAE) attack frequency in the HAELO randomized trial.
HAE attacks dropped by a relative 87% after the single infusion...
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-
CRISPR Gene Therapy Slashes Hereditary Angioedema Attacks
via medpagetoday.com -
In High-Risk B-Cell ALL, Swapping Out Chemo for Blinatumomab Improves Outcomes
via medpagetoday.com(MedPage Today) -- Replacing two high-dose chemotherapy courses with blinatumomab (Blincyto) significantly improved event-free survival (EFS) in pediatric patients with newly diagnosed high-risk B-cell acute lymphoblastic leukemia (ALL), an interim... -
Congo Reports Large Daily Jump in Ebola Cases a Month After Outbreak Was Declared
via medpagetoday.com(MedPage Today) -- KINSHASA, Congo--Congolese authorities have reported one of the highest daily increases in Ebola cases in the month-old outbreak as the virus spreads quickly in a remote region whose shifting population challenges efforts... -
New Type of Maggots Cleared by FDA as Medical Treatment
via medpagetoday.com(MedPage Today) -- The FDA cleared medical-grade Australian sheep blowfly (Lucilia cuprina) larvae in what maker Cuprina Holdings believes marks the first debridement product to use this particular species.
Dubbed Medifly Maggots, the product... -
Newborn Girls Appear Less Likely to Get Vitamin K, Hepatitis B Shots
via medpagetoday.com(MedPage Today) -- Newborn girls were less likely to receive vitamin K prophylaxis and hepatitis B vaccination than newborn boys, according to a cohort study involving more than 93,000 babies.
Female sex was associated with non-receipt of vitamin... -
Diabetes Patients on Semaglutide Had Fewer Fractures, Study Finds
via medpagetoday.com(MedPage Today) -- CHICAGO--The GLP-1 receptor agonist semaglutide (Ozempic, Wegovy) was associated with a 15% lower risk for fractures in adults with type 2 diabetes, a review of medical records found.
In a matched analysis involving more... -
Novel Hereditary Angioedema Treatments on the Horizon
via medpagetoday.com(MedPage Today) -- Novel hereditary angioedema (HAE) drugs aim to push treatment and prevention toward more convenient, long-acting agents and gene-editing cures by targeting plasma kallikrein and the contact activation cascade to prevent uncontrolled... -
'The Pitt' Finale Was 2 Months Ago. We Can't Stop Thinking About This Scene.
via medpagetoday.com(MedPage Today) -- Watching season two of "The Pitt," we found ourselves pulled into one of the show's quieter moments, when two exhausted trainees sat outside the ambulance bay entrance to the emergency department at the end of a brutal shift... -
ED Docs Being Replaced by Private Equity-Owned Firm Call It a 'Kick in the Teeth'
via medpagetoday.com(MedPage Today) -- Emergency medicine physicians under contract with Valley Health in Winchester, Virginia, said they were blindsided by the news that the health system planned to end their contract and partner with a private-equity owned practice... -
COVID Shots Tied to Lower Risks of Heart Attack, Cardiac Death
via medpagetoday.com(MedPage Today) -- COVID-19 vaccines were associated with a lower risk of major adverse cardiovascular events (MACE), in addition to other outcomes, particularly among older adults, according to three studies.
Among over 1 million veterans who... -
What to Know About Alpha-Gal Syndrome, the Life-Threatening, Tick-Borne Meat Allergy
via medpagetoday.com(MedPage Today) -- It's common knowledge that ticks can spread infections that cause serious illnesses, including Lyme disease. Now health officials are trying to raise awareness of a lesser-known problem: alpha-gal syndrome, a life-threatening... -
Teplizumab Approval Expands to Early Type 1 Diabetes
via medpagetoday.com(MedPage Today) -- The FDA expanded the approval of teplizumab (Tzield) to include pediatric patients 8 years and older who have recently been diagnosed with stage 3 type 1 diabetes, the clinical stage where hyperglycemia symptoms emerge and insulin... -
FDA Clears First OTC Continuous Glucose Monitor for Kids
via medpagetoday.com(MedPage Today) -- The FDA cleared the first over-the-counter (OTC) integrated continuous glucose monitor (CGM) for children 2 years and older with or without diabetes, the agency announced on Friday.
The Stelo Glucose Biosensor System device... -
Mitch McConnell Hospitalized; Outbreak Deaths Reach 181; iPhones and Birth Rates
via medpagetoday.com(MedPage Today) -- Note that some links may require registration or subscription.
Sen. Mitch McConnell (R-Ky.), age 84, was admitted to the hospital with an undisclosed condition. (The Hill)
The CDC alerted about three babies hospitalized with... -
Medicare Should Pay Docs More, Cut Nursing Home and Home Health Pay, MedPAC Says
via medpagetoday.com(MedPage Today) -- The Medicare Physician Fee Schedule should increase each year tied to the rate of medical inflation, while payments for inpatient rehabilitation and home healthcare should be cut, the Medicare Payment Advisory Commission (MedPAC... -
Australian pharmacy group pulls out of $10bn talks to buy Boots
via ft.comSigma Healthcare says deal for UK retailer would not meet its strategic objectives -
Not Enough Men On Testosterone Get Guideline-Based Hypogonadism Work-Up
via medpagetoday.com(MedPage Today) -- CHICAGO--Few men prescribed testosterone therapy received guideline-concordant diagnostic testing for androgen deficiency, and some received therapy despite contraindications, a retrospective chart review indicated.
In a... -
Less Than 1% of Hypertension Cases Screened for Primary Aldosteronism
via medpagetoday.com(MedPage Today) -- CHICAGO--One in 12 patients with incident hypertension screened positive for primary aldosteronism, suggesting expanded screening may boost detection, according to a real-world cohort study.
Among 2.5 million adults with... -
'We've Actually Got Millions of People to Think About It': What We Heard This Week
via medpagetoday.com(MedPage Today) -- "By the actions of the ADA, we've actually got millions of people to think about it."--Steven Kahn, MBChB, editor-in-chief of Diabetes Care, on being kicked out of the American Diabetes Association (ADA) meeting after distributing... -
Diabetes Tied to Higher Death Risk After Solid Organ Transplant
via medpagetoday.com(MedPage Today) -- CHICAGO--Diabetes was linked with an increased risk of death among transplant recipients of four major organs, with pre-existing and new-onset diabetes both implicated, a comprehensive analysis of four types of solid-organ... -
The World Cup Is a Celebration of Sport. It's Also a Warning About Climate Change.
via medpagetoday.com(MedPage Today) -- Over the next month, millions of fans will gather across North America for the FIFA World Cup. Stadiums will fill with cheering crowds. Young athletes will dream of representing their countries one day. Communities will celebrate... -
GLP-1 and SGLT2 Users Face Different Risk for Diabetic Foot Complication
via medpagetoday.com(MedPage Today) -- CHICAGO--Use of GLP-1 receptor agonists was tied to significantly lower risks of major diabetic foot complications compared with SGLT2 inhibitors in adults with type 2 diabetes, a large, real-world analysis indicated.
Compared... -
Visceral Fat and Cardiometabolic Risk Factors; Autoantibodies and IBD
via medpagetoday.com(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of Texas Tech Health El Paso, look at the top medical... -
In Our Dog-Eat-Dog Medical Culture, Physicians Lose
via medpagetoday.com(MedPage Today) -- For years, physicians have voiced the same frustrations: declining reimbursement, increasing administrative burden, private equity infiltration, insurance company control, expanding scope creep, artificial intelligence (AI) anxiety... -
FDA's E-Cigarette Authorization: Fruity Vapes Not Better Than Tobacco Ones
via medpagetoday.com(MedPage Today) -- Fruit-flavored e-cigarettes recently authorized by the FDA were not significantly better at helping smokers quit than tobacco-flavored e-cigarettes, according to a new memo that's likely to stir new questions about the agency... -
Endocrine Society Issues First Guideline on Central Precocious Puberty
via medpagetoday.com(MedPage Today) -- CHICAGO--For kids with central precocious puberty (CPP), there shouldn't be a one-size-fits-all approach to testing and treatment, according to a clinical practice guideline from the Endocrine Society.
The guideline, the... -
Talquetamab Regimens Boost Survival in Multiple Myeloma
via medpagetoday.com(MedPage Today) -- Talquetamab (Talvey) plus daratumumab (Darzalex) with or without pomalidomide (Pomalyst) significantly improved survival outcomes over an active regimen for relapsed or refractory multiple myeloma, a phase III trial showed.... -
Study Linking Vaccines to Autism Retracted
via medpagetoday.com(MedPage Today) -- A 2010 paper that linked hepatitis B vaccines in infant boys to an increased risk of autism diagnosis was retracted and another study by the same authors is under investigation.
The study, published in the Journal of Toxicology... -
Drinking in Pregnancy on the Rise, CDC Data Show
via medpagetoday.com(MedPage Today) -- Alcohol consumption during pregnancy has been on the rise in recent years, with some groups, like unmarried women and women in frequent distress, more likely to partake, CDC data showed.
Responding to a survey, 15.2% of pregnant... -
FDA Approves Prostate Cancer Combo That Warranted Advisory Meeting
via medpagetoday.com(MedPage Today) -- The FDA approved capivasertib (Truqap) in combination with abiraterone (Zytiga) and prednisone for PTEN-deficient prostate cancer, the agency announced on Friday.
Approval stipulates use in metastatic hormone-sensitive prostate...
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