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-
Here’s what space toilets can teach us about finding signs of alien life
Lessons learned from flushing space toilets can help researchers plan life-hunting missions to icy moons. -
How volcanoes may have ended the dynasty of Ptolemy and Cleopatra
Volcanic ash in polar ice reveal a link between eruptions and the timing of revolts in Cleopatra’s Egypt. -
Why seeing a star crash is a 'watershed moment in astrophysics'
via cbc.caGravitational waves have led scientists to something they’ve never seen before — the collision of two exotic objects called neutron stars. Here are some amazing things about that discovery. -
Google sister company makes 'bold bet' with new tech-focused neighbourhood 'Sidewalk Toronto'
via cbc.caWaterfront Toronto has announced that Sidewalk Labs, Google’s city-building sister company, will be its partner in creating a new tech-focused neighbourhood on the eastern Toronto waterfront. -
Tuning insulin sensitivity by exosome
Adipose tissue macrophages release exosomes containing microRNAs that modulate insulin sensitivity. -
The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1
Senescent cells withdraw from the cell cycle and do not proliferate. The prevalence of senescent compared to normally functioning parenchymal cells increases with age, impairing tissue and organ homeostasis. A contentious principle governing this process has been the redox theory of aging. We linked matricellular protein thrombospondin 1 (TSP1) and its receptor CD47 to the activation of NADPH oxidase 1 (Nox1), but not of the other closely related Nox isoforms, and associated oxidative stress, an -
Resveratrol stimulates the metabolic reprogramming of human CD4+ T cells to enhance effector function
The polyphenol resveratrol activates the deacetylase Sirt1, resulting in various antioxidant, chemoprotectant, neuroprotective, cardioprotective, and anti-inflammatory properties. We found that at high concentrations of resveratrol, human CD4+ T cells showed defective antigen receptor signaling and arrest at the G1 stage of the cell cycle, whereas at low concentrations, cells were readily activated and exhibited enhanced Sirt1 deacetylase activity. Nevertheless, low-dose resveratrol rapidly stim -
Papers of note in Science Translational Medicine 9 (411)
This week’s articles describe ways to potentially prevent heart failure after myocardial infarction and treat the autoimmune disease plaque psoriasis. -
Papers of note in Science 358 (6360)
This week’s articles identify distinct mechanisms of apoptosis in different areas of the germinal center and present an interactive virtual fly embryo that shows the expression of signaling pathway components and other regulatory molecules in individual cells. -
Papers of note in Nature 550 (7675)
The articles highlighted this week focus on signaling events that control appetite and weight; the effects of Hippo signaling on cell function during cardiac repair; a mechanism that drives cancer drug addiction; inactivation of a kinase complex by structural rearrangement; and the mechanism by which a noncoding viral RNA inhibits host cell apoptosis. -
Olfactory experience primes the heat shock transcription factor HSF-1 to enhance the expression of molecular chaperones in C. elegans
Learning, a process by which animals modify their behavior as a result of experience, enables organisms to synthesize information from their surroundings to acquire resources and avoid danger. We showed that a previous encounter with only the odor of pathogenic bacteria prepared Caenorhabditis elegans to survive exposure to the pathogen by increasing the heat shock factor 1 (HSF-1)–dependent expression of genes encoding molecular chaperones. Experience-mediated enhancement of chaperone gen -
This stretchy implant could help kids avoid repeated open-heart surgeries
A new type of surgical implant grows along with its recipient. -
Angler nearly dies after swallowing fish he was trying to kiss
via cbc.caSam Quilliam tried to kiss a fish but it jumped down his throat and sent him into cardiac arrest. He tells us about his near-death experience and his quick-thinking friends who helped save his life. -
Self-driving cars could ease traffic, but increase sprawl
via cbc.caA new study inspired by Boston's early experiments with self-driving cars finds that the technology could ease congestion, but might also lead to more cars on the road and further encourage urban sprawl. -
Here’s a breakdown of the animals that crossed the Pacific on 2011 tsunami debris
Hundreds of marine animals from Japan have washed up on U.S. beaches since the destructive 2011 earthquake and tsunami. -
'If we thought it was bad, it's worse:' Alberta methane releases underestimated
via cbc.caNew research suggests industry and government are badly underestimating Alberta's emissions of one of the most potent greenhouse gases. -
Timing of melanoma diagnosis, treatment critical to survival
A new study underscores the importance of early detection and treatment of melanoma, the deadliest form of skin cancer. The research indicates that the sooner patients were treated, the better their survival, particularly for stage I melanoma. -
'Hiding in plain sight:' Discovery raises questions over scale of overlooked biodiversity
Scientists have used cutting edge DNA technology to demonstrate that one of Europe's top freshwater predators is actually two species rather than one. -
World first for reading digitally encoded synthetic molecules
For the first time ever, using mass spectrometry, researchers have successfully read several bytes of data recorded on a molecular scale using synthetic polymers. Their work sets a new benchmark for the amount of data -- stored as a sequence of molecular units (monomers) -- that may be read using this routine method. It also sets the stage for data storage on a scale 100 times smaller than that of current hard drives. -
Nearly half of US medical care comes from emergency rooms
Nearly half of all US medical care is delivered by emergency departments, according to a new study. In recent years, the percentage of care delivered by emergency departments has grown. The paper highlights the major role played by emergency rooms in US health care. -
Many pelvic tumors in women may have common origin: Fallopian tubes
Most, and possibly all, ovarian cancers start, not in ovaries, but instead in the fallopian tubes attached to them, report investigators. -
Keratin, proteins from 54-million-year-old sea turtle show survival trait evolution
Researchers have retrieved original pigment, beta-keratin and muscle proteins from a 54-million-year-old sea turtle hatchling. The work adds to the growing body of evidence supporting persistence of original molecules over millions of years and also provides direct evidence that a pigment-based survival trait common to modern sea turtles evolved at least 54 million years ago. -
Secret Microsoft database of unfixed vulnerabilities hacked in 2013
via cbc.caHackers broke into a secret Microsoft database containing information about critical and unfixed vulnerabilities in Windows and other popular software in 2013, former employees disclose. -
A universal flu shot may be nearing reality
Scientists are developing a universal vaccine against flu, making annual shots a thing of the past. -
New VR Tech Aims to Take Surround-Sound to the Next Level
via rss.sciam.comSpatial audio promises immersive virtual experiences that engage more of the senses
-- Read more on ScientificAmerican.com -
New VR Tech Aims to Take Surround-Sound to New Levels
via rss.sciam.comSpatial audio promises immersive virtual experiences that engage more of the senses
-- Read more on ScientificAmerican.com -
Saving the Endangered Cuban Crocodile
via rss.sciam.comHybridization poses an increasing threat to the nation’s beloved reptile
-- Read more on ScientificAmerican.com -
Disability in demand: People with autism offer employers a broader talent pool
via cbc.caA Danish company with a global mandate to help employers make the most of untapped autistic talent is helping North American firms make concerted efforts to hire employees with autism who can bring unique skills to the workplace. -
Youth football: How young athletes are exposed to high-magnitude head impacts
(Journal of Neurosurgery Publishing Group) Researchers examined exposure to high-magnitude head impacts (accelerations greater than 40g) in young athletes, 9 to 12 years of age, during football games and practice drills to determine under what circumstances these impacts occur and how representative practice activities are of game activities with respect to the impacts. This type of information can help coaches and league officials make informed decisions in structuring both practices and games -
You would not ask a firefighter to perform open-heart surgery
(Iowa State University) The concept of 'collective intelligence' is simple -- it asserts that if a team performs well on one task, it will repeat that success on other projects, regardless of the scope or focus of the work. While it sounds good in theory, it doesn't work that way in reality, according to an Iowa State University researcher. -
Worms learn to smell danger
(University of Iowa) University of Iowa researchers report that a roundworm can learn to put on alert a defense system important for protecting cells from damage. The finding could lead to a new approach for treating neurodegenerative diseases in humans caused by damaged cells. -
Wits team involved in international breakthrough in astronomical observation
(University of the Witwatersrand) For the first time in history, Wits researchers have witnessed electromagnetic signals that are associated with the gravitational wave emission from the coalescence of two massive neutron stars. -
Wearables to boost security of voice-based log-in
(University of Michigan) A security-token necklace, ear buds or eyeglasses developed at the University of Michigan could eliminate vulnerabilities in voice authentication -- the practice of logging in to a device or service with your voice alone. -
Volcanic eruptions linked to social unrest in Ancient Egypt
(Future Earth) Did volcanic eruptions in the planet's high northern latitudes play a role in causing violent rebellions in Ancient Egypt? A new study suggests that the answer is yes. Researchers examined a range of evidence -- from climate records to papyri -- finding a close link between eruptions and political unrest in the Ptolemaic era. The connection comes from the capacity of volcanoes to cool the atmosphere, which can, in turn, disrupt the flow of the Nile River. -
Using satellite data to respond to environmental disasters in Malaysia, Ethiopia and Kenya
(University of Oxford) The challenge of providing a rapid response to environmental disasters as varied as flooding, drought, illegal logging and oil spills is the focus of two new projects in which the University of Oxford is a key partner. -
USDA invests in research on next generation of agricultural technology
(National Institute of Food and Agriculture ) The US Department of Agriculture's (USDA) National Institute of Food and Agriculture (NIFA) today announced 17 grants for research on the next generation of agricultural technologies and systems to meet the growing demand for food, fuel, and fiber. The grants are funded through NIFA's Agriculture and Food Research Initiative (AFRI), authorized by the 2014 Farm Bill. -
UB spinoff company For-Robin moves one step closer to human clinical trials
(University at Buffalo) Scientists from For-Robin Inc., a University at Buffalo biotechnology spinoff, have published new scientific results showing that the company's cancer-fighting antibody can target, penetrate and kill human tumor cells effectively. The findings bring the company closer to human clinical trials. -
To keep Saturn's A ring contained, its moons stand united
(Cornell University) For three decades, astronomers thought that only Saturn's moon Janus confined the planet's A ring -- the largest and farthest of the visible rings. But after poring over NASA's Cassini mission data, Cornell astronomers now conclude that the teamwork of seven moons keeps this ring corralled. -
Therapeutic form of arsenic is a potential treatment for deadly type of brain cancer
(The Translational Genomics Research Institute) In a study led by Northwestern University Feinberg School of Medicine and the Translational Genomics Research Institute (TGen), this anti-cancer agent is being considered for use against glioblastoma multiforme (GBM), the most common and aggressive type of deadly brain tumors. The study was published today in Molecular Cancer Research, a journal of the American Association for Cancer Research (AACR). -
TGen develops processing procedures for 'single-cell' sequencing
(The Translational Genomics Research Institute) The Translational Genomics Research Institute (TGen) today announced grant support from the Chan Zuckerberg Initiative (CZI) donor advised fund, an advised fund of the Silicon Valley Community Foundation, that will help revolutionize how researchers identify the genetic source of diseases and how best to treat each patient. -
Study shows how water could have flowed on 'cold and icy' ancient Mars
(Brown University) Research by planetary scientists at Brown University finds that periodic melting of ice sheets on a cold early Mars would have created enough water to carve the ancient valleys and lakebeds seen on the planet today. -
Study reshapes understanding of climate change's impact on early societies
(Yale University) A new study linking paleoclimatology -- the reconstruction of past global climates --with historical analysis by researchers at Yale and other institutions shows a link between environmental stress and its impact on the economy, political stability, and war-fighting capacity of ancient Egypt. -
Study links chocolate production to increased deforestation in poor nations
(Lehigh University) In newly published research, Mark Noble, visiting assistant professor of sociology and anthropology at Lehigh, focuses on the link between cocoa exports and deforestation in developing nations. -
Signaling pathway may be key to why autism is more common in boys
(University of Iowa Health Care) Researchers led by Ted Abel, director of the Iowa Neuroscience Institute at the University of Iowa, have discovered sex differences in a brain signaling pathway involved in reward learning and motivation that make male mice more vulnerable to an autism-causing genetic glitch. -
Scientists create most powerful micro-scale bio-solar cell yet
(Binghamton University) Researchers at Binghamton University, State University of New York have created a micro-scale biological solar cell that generates a higher power density for longer than any existing cell of its kind. -
Schizophrenia disrupts the brain's entire communication system, researchers say
(University of Southern California) Some 40 years since CT scans first revealed abnormalities in the brains of schizophrenia patients, international scientists say the disorder is a systemic disruption to the brain's entire communication system. The study sets the stage for future research on the debilitating mental illness that affects more than 21 million people worldwide. It is the largest analysis of 'white matter' differences in a psychiatric disorder to date. -
Saving hearts after heart attacks: Overexpression of a gene enhances repair of dead muscle
(University of Alabama at Birmingham) University of Alabama at Birmingham biomedical engineers report a significant advance in efforts to repair a damaged heart after a heart attack, using grafted heart-muscle cells to create a repair patch. The key was overexpressing a gene that activates the cell-cycle of the grafted muscle cells, so they grow and divide more than control grafted cells. -
RIT hosts Hockey Analytics Conference Oct. 21
(Rochester Institute of Technology) The latest research in analytics for college and professional hockey -- and for sports in general -- will be explored at the third annual Rochester Institute of Technology Hockey Analytics Conference. -
'Revising the image of Islamic law'
(Cluster of Excellence "Religion and Politics") Scholar of Islamic studies Norbert Oberauer explores the unknown legal genre of the 'maxims' - Study sheds new light on the legal history of Islam: far more alterations from the Middle Ages to the modern age than expected -- Formulas of the maxims systematized the law, an innovative step in history that had long been overlooked. -
Resolving traffic jams in human ALS motor neurons
(VIB (the Flanders Institute for Biotechnology)) A team of researchers at VIB and KU Leuven used stem cell technology to generate motor neurons from ALS patients carrying mutations in FUS. They found disturbed axonal transport in these motor neurons, but also identified genetic and pharmacological strategies that mitigate this defect.
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