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-
These spiders may have the world’s fastest body clocks
Three orb-weaving spiders may have the shortest circadian clocks yet discovered among animals. -
Zwicky Transient Facility sees 'first light'
A new robotic camera that can capture hundreds of thousands of stars and galaxies in a single shot has taken its first image -- an event astronomers refer to as 'first light.' The camera is the centerpiece of a new automated sky survey called the Zwicky Transient Facility (ZTF). -
Simulating the universe using Einstein’s theory of gravity may solve cosmic puzzles
Better simulating the dense parts of the universe could improve scientists’ view of how the universe evolves. -
Scientists create yellow, three-eyed, wingless mosquitoes by using gene editing tool
Researchers have developed transgenic mosquitoes that stably express the Cas9 enzyme in their germline. The addition of Cas9 will enable the use of the CRISPR gene editing tool to make efficient, targeted changes to the mosquitoes' DNA. As proof of concept, the researchers used the system to disrupt cuticle, wing, and eye development, producing completely yellow, three-eyed and wingless mosquitoes. Their long-term goal is to develop new pest control strategies. -
Labor induction at 40 weeks associated with lower risk of perinatal mortality
Induction of labor at 40 weeks in nulliparous women aged 35 and older is associated with reduced risk of in-hospital perinatal death, according to a recent analysis. -
Disease-resistant apples perform better than old favorites
You may not find them in the produce aisle yet, but it's only a matter of time before new disease-resistant apple cultivars overtake favorites like Honeycrisp in popularity. -
The genetics of PKM{zeta} and memory maintenance
Elucidating the molecular mechanisms that maintain long-term memory is a fundamental goal of neuroscience. Accumulating evidence suggests that persistent signaling by the atypical protein kinase C (PKC) isoform protein kinase M (PKM) might maintain synaptic long-term potentiation (LTP) and long-term memory. However, the role of PKM has been challenged by genetic data from PKM-knockout mice showing intact LTP and long-term memory. Moreover, the PKM inhibitor peptideinhibitory peptide (ZIP) revers -
Papers of note in Science Translational Medicine 9 (415)
This week’s articles describe a way to combat the negative effects of stress on cancer therapy; a potential target in heart failure; and why nighttime wounds heal more slowly than daytime wounds. -
Papers of note in Science 358 (6364)
This week’s articles highlight a newly identified component of methionine sensing; a mechanism by which nutrient depletion prevents the efflux of essential amino acids from lysosomes; how reactive oxygen species promote genome stability during metabolic stress; co-option of the cell cycle regulatory machinery to time the differentiation of multiciliated cells; and connections between olfaction, organismal metabolism, and longevity. -
Papers of note in Nature 551 (7679)
This week’s articles highlight interactions between astrocytes and neurons that influence both cell types’ form and function; a genetic basis for individual variation in aging; and the mechanism by which an E3 ubiquitin ligase adaptor affects synaptic transmission. -
MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia
Activating mutations in the gene encoding the cell-cell contact signaling protein Notch1 are common in human T cell acute lymphoblastic leukemias (T-ALLs). However, expressing Notch1 mutant alleles in mice fails to efficiently induce the development of leukemia. We performed a gain-of-function screen to identify proteins that enhanced signaling by leukemia-associated Notch1 mutants. The transcription factors MAFB and ETS2 emerged as candidates that individually enhanced Notch1 signaling, and whe -
Isolation of isoform-specific binding proteins (Affimers) by phage display using negative selection
Some 30 years after its discovery, phage display remains one of the most widely used methods of in vitro selection. Initially developed to revolutionize the generation of therapeutic antibodies, phage display is now the first choice for screening artificial binding proteins. Artificial binding proteins can be used as reagents to study protein-protein interactions, target posttranslational modifications, and distinguish between homologous proteins. They can also be used as research and affinity r -
Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology
Because protein-protein interactions underpin most biological processes, developing tools that target them to understand their function or to inform the development of therapeutics is an important task. SUMOylation is the posttranslational covalent attachment of proteins in the SUMO family (SUMO-1, SUMO-2, or SUMO-3), and it regulates numerous cellular pathways. SUMOylated proteins are recognized by proteins with SUMO-interaction motifs (SIMs) that facilitate noncovalent interactions with SUMO. -
Fat expansion through norepinephrine catabolism
Certain macrophage populations limit norepinephrine-induced lipolysis in adipose tissues in response to aging or obesity. -
Climate change making Harvey's 'Biblical' rainfall more likely, study says
via cbc.caThe chances of a hurricane flooding parts of Texas, like Harvey did, have soared six-fold in just 25 years because of global warming and will likely triple once again before the end of the century, a new study says. -
U.S. approves digital pill that tracks when patients take it
(Reuters) - U.S. regulators have approved the first digital pill with an embedded sensor to track if patients are taking their medication properly, marking a significant step forward in the convergence of healthcare and technology. -
Stranded orca refloated in New Zealand
via bbc.co.ukVolunteers and military personnel worked together to help return the killer whale to the ocean. -
Into the woods: The Japanese way to beat stress
via bbc.co.ukOne army veteran suffering from PTSD says Forest Bathing is helping him sleep. -
The brain auditions different cells when learning a task, some don't make the cut
For decades, neuroscientists have wondered how the brain can continue to learn new skills without needing to grow in size or volume over a person's lifetime. Evidence suggests that the number of brain cells -- neurons, synapses, and glial cells -- does initially increase as we're learning, but many are eventually pruned away or assigned to other roles. -
Electron backscatter diffraction yields microstructure insights
Soft magnetic core engineering plays a key role in high-efficiency electric motors, but for higher-frequency applications, soft magnetic composites are also promising. Each stage of motor construction affects the material's microstructure, and understanding the details of the microstructure is paramount to reaching higher efficiency for electrical motors. Researchers have now created an advanced characterization method to closely examine microscale structural characteristics and changes during m -
Artificially cooling planet 'risky strategy'
Proposals to reduce the effects of global warming by imitating volcanic eruptions could have a devastating effect on global regions prone to either tumultuous storms or prolonged drought, new research has shown. -
Sun's role in mitigating fungal disease of mango fruit
The occurrence of stem end rot (SER) during storage means major losses for mango fruit growers and suppliers. Promising new research explores sunlight's role in cultivating a beneficial mix of microorganisms that help mitigate SER. -
Psoriasis severity linked to increased risk of type 2 diabetes
People with psoriasis are at a higher risk to develop type 2 diabetes than those without psoriasis, and the risk increases dramatically based on the severity of the disease. Researchers found people with psoriasis that covers 10 percent of their body or more are 64 percent more likely to develop diabetes than those without psoriasis, independent of traditional risk factors such as body weight. -
Pesticides may cause bumblebees to lose their buzz, study finds
Pesticides significantly reduce the number of pollen grains a bumblebee is able to collect, a new study has found. -
New insights into why sleep is good for our memory
Researchers have shed new light on sleep's vital role in helping us make the most of our memory. -
Low dose, constant drip: Pharmaceutical, personal care pollution impacts aquatic life
Traditional toxicity testing underestimates the risk that pharmaceutical and personal care product pollution poses to freshwater ecosystems. Criteria that account for ecological disruption -- not just organism death -- are needed to protect surface waters, which are under pressure from a growing population and escalating synthetic chemical use. -
Combating devastating amphibian disease
Amphibian chytridiomycosis, caused by infection with the Batrachochytrium dendrobatidis fungus, is the most devastating vertebrate disease on record. -
'Black box' methods used by biologists probably overestimate number of new species
New research demonstrates the misuse and abuse of methods scientists commonly use to place boundaries between different species. -
Aspirin can prevent heart attacks after noncardiac surgery in patients with prior PCI
A new study has found that perioperative aspirin can prevent heart-related complications after major noncardiac surgery in patients with previous percutaneous coronary intervention (PCI) such as an angioplasty or stent. The study found that for every 1,000 patients with PCI, giving them aspirin at the time of noncardiac surgery would prevent 59 heart attacks and cause eight major bleeding events. -
Study settles prehistoric puzzle, confirms modern link of carbon dioxide and global warming
Fossil leaves from Africa resolve a prehistoric climate puzzle and confirm the link between carbon dioxide and global warming. Research previously found conflicting data on high carbon levels and its link to climate change about 22 million years ago. But a new study found the link existed then as now. The finding sheds light on recent and future increases in atmospheric carbon and its impact on our planet. -
Global birth season study links environment with disease risk
A new study sheds light on connections between birth month and risk for certain diseases. -
Why testicular cancer is so responsive to chemo
A major step has been taken toward answering a key question in cancer research: Why is testicular cancer so responsive to chemotherapy, even after it metastasizes? -
Canadians more web-connected, but at possible cost to work-life balance, StatsCan says
via cbc.caCanadians are leading more and more digitally connected lives, and that's having both positive and negative implications on our well-being, a new Statistics Canada survey suggests. -
New camera on Palomar telescope will seek out supernovas, asteroids and more
The Zwicky Transient Facility at Palomar Observatory in California will seek supernovas, black holes and asteroids. -
FDA approves first digital pill to track when patients take medication
via cbc.caAmerican regulators have approved the first drug with a sensor that can track whether patients have taken their medicine. -
Surgeons repair spina bifida in fetus for 1st time in Canada, hospitals say
via cbc.caFor the first time in Canada, a team of surgeons has successfully performed in-utero surgery to repair a form of spina bifida, two Toronto hospitals say. -
Why hot water freezes faster than cold water
A team of researchers has defined a theoretical framework that could explain the Mpemba effect, a counterintuitive physical phenomenon revealed when hot water freezes faster than cold water. -
Sensor for the most important human cancer gene
The molecular smoke detector works like a TP53 sensor, which monitors the correct function of the gene. A non-functional TP53 gene is going to activate the sensor, which initiates cell death. -
Parasitic plants rely on unusual method to spread their seeds
Three species of non-photosynthetic plants rely mainly on camel crickets to disperse their seeds. -
Oral bacteria in the gut could drive immune cell induction and inflammatory bowel disease
Investigators have investigated the relationship between salivary microbes and IBD, and they found that when the bacterium Klebsiella pneumoniae colonizes in an intestine out of microbial balance, immune cells called T helper 1 (TH1) become overactive in the gut, resulting in intestinal inflammation leading to the onset of IBD. -
Innovative, ideal liquid-repellent surfaces developed by scientists
Scientists have developed a robust liquid-repellent structure and the fabrication of porous surfaces by an innovative microfluidic-droplet-based technique. Materials such as textiles, metals, and glasses covered by a layer of this robust porous surface can then become liquid-repellent. -
Ethnic and gender differences in youths' developing gender identity
The extent to which youths feel typical of their gender and the pressure they feel to conform to traditional gender roles are related to adolescents' well-being. Because many gender-related expectations are culturally based, a new longitudinal study examined how French middle school adolescents' feelings about the development of gender identity differed across groups of teens from different ethnicities, cultures, and genders. -
Allergy amplifier implicated in asthma also intensifies food allergy
Almost 8 percent of children under three years old and four percent of adults suffer food allergies, which trigger not only discomfiting symptoms like dermatitis and diarrhea but can cause deadly anaphylactic shock. Allergic responses emerge when food components, like egg, shellfish, or peanut proteins, stimulate white blood cells called mast cells to dump excessive quantities of histamine or cytokines into the blood, fomenting inflammation in skin, eyes, or gastrointestinal tract, among other t -
Cognitive behavioral therapy for children and adolescents with OCD works in the long run
The vast majority of children and adolescents who receive cognitive behavioral therapy treatment for OCD thrive and live without symptoms a year after the end of treatment, shows new research. -
Evidence-based approach to treating post-delivery pain in new moms during opioid crisis
Women who undergo vaginal delivery often do not require opioids to manage pain after hospital discharge, concludes a study. In addition, the quantity of opioids prescribed to women after cesarean delivery can be less than currently prescribed, say the authors. -
How food poisoning bacteria Campylobacter uses other organisms as Trojan horse to infect new hosts
New research has shown how the food poisoning bacteria Campylobacter can multiply and spread inside micro-organisms called amoebae- which could lead to a better understanding of how bacteria survive and help efforts to prevent the spread of infection. -
Grow, differentiate and freeze stem cells in a transparent bag
Human stem cells are considered a major new hope in the field of medicine. In the future, it is expected that they will make it possible to treat a wide range of ailments such as neurodegenerative diseases. With LabBag®, researchers have developed an all-in-one system in the form of a transparent bag that provides a cheap, fast and sterile way for scientists to grow, differentiate and freeze stem cells. The cell models produced can be used for toxicity tests and drug development. -
Tapeworm drug fights prostate cancer
Medicine against parasites like Tapeworms and Giardia, contains a substance that kills Prostate- and colon cancer, scientists have discovered. -
Quick! What's that smell? Mammal brains identify type of scent faster than once thought
It takes less than one-tenth of a second -- a fraction of the time previously thought -- for the sense of smell to distinguish between one odor and another, new experiments in mice show. -
HPV testing is better than the Pap test at detecting cervical cancer
Testing for cervical cancer using HPV testing in addition to the Pap smear is unlikely to detect cancer cases that wouldn't be found using HPV testing alone.
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