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Mitochondrial DNA Varies between Mitochondria within Individual Cells
To find better ways of diagnosing and treating mitochondrial diseases, scientists sift through mitochondrial DNA—and they have just started to use a very fine screen. At the University of Pennsylvania School of Medicine, researchers led by James Eberwine, Ph.D., have developed a means of sequencing the DNA of individual mitochondria. The researchers have used this method, single-mitochondrion sequencing, to detect previously indiscernible—and likely meaningful—variability in mi -
Fate Therapeutics, UC San Diego Launch CAR NK Cancer Immunotherapy Collaboration
Fate Therapeutics said today it will develop off-the-shelf, chimeric antigen receptor (CAR)-targeted natural killer (NK) cell cancer immunotherapies through a research collaboration with the University of California, San Diego.The collaboration—whose value was not disclosed—will be led by Dan S. Kaufman, M.D., Ph.D., director of cell therapy at UC San Diego School of Medicine and a professor of medicine in the school’s Division of Regenerative Medicine.On November 30, Dr. Kaufm -
UMD's Dr. Rita Colwell Awarded 2017 International Prize for Biology
The 33 rd International Prize for Biology has been awarded to Rita Colwell, Ph.D., Distinguished University Professor, University of Maryland. She was cited for her outstanding contributions to marine microbiology, bioinformatics, and the understanding and prevention of cholera.Dr. Colwell, whose career bridges the disciplines of microbiology, ecology, infectious disease, public health, and computer and satellite technology, continues to be a leader in bioinformatics, notably in understand -
Trace Element in Drinking Water Slows Alzheimer’s Death Rate
Researchers at Brock University in Ontario have recently found an interesting correlation between Alzheimer’s disease (AD) and drinking water—and no, it doesn’t have to do with the government lacing the water with mind-altering compounds. The researchers collected statistics on the levels of lithium in drinking water in 234 counties across the state of Texas. The investigators compared lithium levels naturally found in tap water with AD mortality rates, along with the incidence -
After FDA Approval, Novo Nordisk Eyes 2018 Launch for Once-Weekly Diabetes Treatment Ozempic
Novo Nordisk says it is planning to launch its once-weekly type 2 diabetes treatment Ozempic ® (semaglutide injection) early in 2018 following approval yesterday by the FDA.Ozempic is a glucagon-like peptide 1 (GLP-1) receptor agonist indicated as an adjunct to diet and exercise. The agency authorized the marketing of Ozempic six weeks after the FDA’s Endocrinologic and Metabolic Drugs Advisory Committee recommended approval of the therapy by a 16 to 0 vote with one abstention.The advi -
Multiple Myeloma Patient Survival Associated with ADAR1 Enzyme Levels
Scientists at the University of California San Diego School of Medicine report that high ADAR1 enzyme levels correlate with reduced survival rates among patients with multiple myeloma. They also determined that blocking the enzyme reduces multiple myeloma regeneration in experimental models derived from patient cancer cells. The study (“ Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma ”), published in Nature Communicati
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