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-
Key brain molecule may play role in many brain disorders
Scientists have identified a molecule called microRNA-29 as a powerful controller of brain maturation in mammals. Deleting microRNA-29 in mice caused problems very similar to those seen in autism, epilepsy, and other neurodevelopmental conditions. The results, published in Cell Reports, illuminate an important process in the normal maturation of the brain and point to the possibility that disrupting this process could contribute to multiple human brain diseases. -
Fossil discovery deepens snakefly mystery
The recent discovery of four new species of ancient insects are leading scientists to question the evolutionary history of the snakefly. The fossils, discovered in British Columbia and Washington State, are estimated to be 52 million years old and were unearthed in a region once thought uninhabitable. -
Womens' pain not taken as seriously as mens' pain
Researchers found that when male and female patients expressed the same amount of pain, observers viewed female patients' pain as less intense and more likely to benefit from psychotherapy versus medication as compared to men's pain, exposing a significant patient gender bias that could lead to disparities in treatments. -
Saskatoon youth-led non-profit begins turning plastic bottles into 3D printer materialÂ
via cbc.caTwo Saskatoon high-school students have started a non-profit that is turning plastic waste into something useful. -
Leeds Bradford Airport development plan ruling delayed
The government is to take more time to examine a £150m scheme to redevelop Leeds Bradford Airport. -
Myeloid cell-derived HOCl is a paracrine effector that trans-inhibits IKK/NF-{kappa}B in melanoma cells and limits early tumor progression
The myeloperoxidase (MPO) system of myeloid-derived cells (MDCs) is central to cellular innate immunity. Upon MDC activation, MPO is secreted into phagosomes where it catalyzes the production of hypochlorous acid (HOCl), a potent chlorinating oxidant. Here, we demonstrated that the myeloid lineage–restricted MPO-HOCl system had antitumor effects in early melanoma growth in aged mice. Orthotopic melanomas grew more slowly in immunocompetent MPO+/+ host mice compared to age-matched syngeneic -
Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu2/mGlu4 receptor heterodimers
Metabotropic glutamate receptors (mGluRs) are G protein–coupled receptors that regulate various aspects of central nervous system processing in normal physiology and in disease. They are thought to function as disulfide-linked homodimers, but studies have suggested that mGluRs can form functional heterodimers in cell lines. Using selective allosteric ligands, ex vivo brain slice electrophysiology, and optogenetic approaches, we found that two mGluR subtypes—mGluR2 and mGluR4 (or mGlu -
Biased ligands at opioid receptors: Current status and future directions
The opioid crisis represents a major worldwide public health crisis that has accelerated the search for safer and more effective opioids. Over the past few years, the identification of biased opioid ligands capable of eliciting selective functional responses has provided an alternative avenue to develop novel therapeutics without the side effects of current opioid medications. However, whether biased agonism or other pharmacological properties, such as partial agonism (or low efficacy), account -
ARC unleashes elastase
An antiapoptotic cytoplasmic protein becomes a proapoptotic nuclear protein in diabetes. -
Novel biomarker for glucocorticoids could help tailor treatments
Researchers have uncovered pathways involved in the body's response to glucocorticoid treatments and identified a novel biomarker that could be used to monitor how these drugs work in patients. -
Leptin puts the brakes on eating via novel neurocircuit
A new study in mice describes novel neurocircuitry between midbrain structures that control feeding behaviors that are under modulatory control by leptin, a hormone made by body fat. Since the discovery of leptin in the 1990s, researchers have wondered how leptin can suppress appetite. -
High levels of arsenic and uranium in some wells
A new U.S. Geological Survey study provides an updated, statewide estimate of high levels of naturally occurring arsenic and uranium in private well water across Connecticut. -
Gut microbiome plays role in autism, study finds
A new study has demonstrated that autism spectrum disorder is related to changes in the gut microbiome. -
Scientists reveal elusive inner workings of antioxidant enzyme with therapeutic potential
The enzyme manganese superoxide dismutase (MnSOD) plays a critical role in maintaining human health by keeping the amount of harmful reactive oxygen molecules in cells under control. By using neutron scattering, researchers have now obtained a complete atomic portrait of the enzyme, revealing key information about its catalytic mechanism. The work could help experts develop MnSOD-based treatments and design therapeutics that mimic its antioxidant behavior. -
A novel form of cellular logistics
Biophysicists have shown that a phenomenon known as diffusiophoresis, which can lead to a directed particle transport, can occur in biological systems. -
Bronze Age slab found in France is oldest 3D map in Europe
The Bronze Age engravings are a map of part of Brittany, north-west France, researchers believe. -
To intervene or not to intervene? That is the future climate question
Experts in climate science and ecology are bringing science to bear on the question and consequences of geoengineering a cooler Earth. -
Droughts longer, rainfall more erratic over the last 50 years in most of Western US
Dry periods between rainstorms have become longer and more erratic across the West during the past 50 years. Total yearly rainfall has decreased by about four inches over the last five decades, with rain falling in fewer and sometimes larger storms, along with longer dry intervals between. The longest dry period in each year increased from 20 to 32 days. -
Beef industry can cut emissions with land management, production efficiency
An assessment of 12 different strategies for reducing beef production emissions worldwide found that industry can reduce greenhouse gas emissions by as much as 50% in certain regions, with the most potential in the United States and Brazil. -
COVID-19: Tsunami of chronic health conditions expected, research and health care disrupted
Cardiometabolic diseases including heart disease, obesity, hypertension and type 2 diabetes, are at the crest of an impending tsunami of chronic health conditions as a result of the SARS-CoV-2 pandemic that will affect society for decades. Interventions and universal health care are recommended to focus on prevention of cardiometabolic diseases, including programs that support healthy lifestyle behaviors, blood pressure control, obesity management and tobacco cessation. -
Separating beer waste into proteins for foods, and fiber for biofuels
All brewers experience the same result of the beer-making process: leftover grain. Once all the flavor has been extracted from grains, what's left is a protein- and fiber-rich powder that is used in cattle feed or put in landfills. Scientists now report a new way to extract the protein and fiber and use it to create new types of protein sources, biofuels and more. -
New deadly snake from Asia named after character from Chinese myth 'Legend of White Snake'
The venomous krait that caused the death of famous herpetologist Joseph B. Slowinski turns out to be new to science, according to recent research. The new species, Bungarus suzhenae, was named after the character Bai Su Zhen from the Chinese myth the Legend of White Snake. -
Discovery is key to creating heat-tolerant crops
By 2050, global warming could reduce crop yields by one-third. To modify plants' response to heat, scientists must first understand how plants sense temperature. Researchers have discovered a gene that's key to this process. -
Enjoy the 'dazzling light show' of fireflies — but they also need protection, says researcher
via cbc.caFirefly tourism is brightening spirits of visitors from around the world, but without proper protections — like taking steps to reduce the "carbon footprint of travel" — populations of the so-called lightning bugs could be at risk, according to published research co-authored by a Canadian. -
Interest in municipal solar projects heating up in Alberta
via cbc.caThe Municipal Solar Program started five years ago but 2020 was by far its biggest year: 22 projects were completed and the program saw its energy capacity almost double, from 10 to 19 megawatts. -
Forgotten Memories of Traumatic Events Get Some Backing from Brain-Imaging Studies
via rss.sciam.comA new wave of research seeks neurological signatures for a type of amnesia-- Read more on ScientificAmerican.com -
These fish stole an antifreeze gene from another fish and became natural GMOs
via cbc.caMillions of years before scientists created genetically modified Atlantic salmon with genes from two other fish, nature created genetically modified smelt with a gene from herring, growing evidence suggests. And now the Canadian scientists who first proposed that controversial idea say they have a hunch how nature might have done it. -
Nature genetically modified this fish the way scientists do
via cbc.caMillions of years before scientists created genetically modified Atlantic salmon with genes from two other fish, nature created genetically modified smelt with a gene from herring, growing evidence suggests. And now the Canadian scientists who first proposed that controversial idea say they have a hunch how nature might have done it. -
Having weird, vivid dreams? Sleep researchers say you're far from alone
via cbc.caBeing chased by swarms of bugs is among the unusual dreams people have reported over the past year, according to sleep specialists. -
Young people with autism improved their communication with their families during lockdown
(Universitat Oberta de Catalunya (UOC)) A study conducted by researchers from the Universitat Oberta de Catalunya studied the behaviour of young people who suffer autism spectrum disorder during the strictest lockdown period (March, April, May and June 2020) to lay the foundations for future support more in line with their actual needs. -
Vilcek honors immigrant scientists: Ruth Lehmann, Mohamed Abou Donia, Ibrahim Cissé, Silvi Rouskin
(Vilcek Foundation) The Vilcek Foundation has launched an online celebration to honor the recipients of the 2021 Vilcek Foundation Prizes. Formatted as a microsite, the online celebration recognizes and shares the accomplishments of the 2021 Vilcek Foundation Prizewinners in lieu of the Vilcek Foundation's annual gala. -
UTSA researchers launch study to predict energy use in San Antonio neighborhoods
(University of Texas at San Antonio) Researchers at The University of Texas at San Antonio (UTSA) are surveying households in two San Antonio zip codes, 78230 and 78202, about their energy use, mobility and chronic health conditions. Once the survey is complete, the data will be combined with cell phone GPS datato improve the ability to predict energy demand through time at the neighborhood level. -
US trade sanctions justified response to human rights abuses in China, law expert argues
(University of Kansas) International trade law expert Raj Bhala argues in two new studies that US trade sanctions against China are appropriate responses to Uyghur genocide, Hong Kong violations; should continue -
Understanding fruit fly behavior may be next step toward autonomous vehicles
(Northwestern University) 1. Fruit flies use antennae temperature differences of less than one degree to escape hot temperatures2. Complex decision-making sheds light on ongoing challenges to developing self-driving vehicles3. Principles learned from drosophila research could guide better, more efficient control systems for autonomous vehicles -
Tiny brains grown in 3D-printed bioreactor
(American Institute of Physics) Scientists have grown small amounts of self-organizing brain tissue, known as organoids, in a tiny 3D-printed system that allows observation while they grow and develop. The advance uses 3D printing to create a reusable and easily adjustable platform that costs only about $5 per unit to fabricate, and the design includes imaging wells for the growing organoids and microfluidic channels to provide a nutrient medium and preheating that supports tissue growth. -
The Lancet Psychiatry: Largest study to date suggests link between COVID-19 infection and subsequent mental health and neurological conditions
(The Lancet) One in three COVID-19 survivors received a neurological or psychiatric diagnosis within six months of infection with the SARS-CoV-2 virus, an observational study of more than 230,000 patient health records published in The Lancet Psychiatry journal estimates. The study looked at 14 neurological and mental health disorders [1]. -
The GovLab, AFD, and Expertise France fund COVID-19 data projects in Africa
(NYU Tandon School of Engineering) The Governance Lab (GovLab) at the NYU Tandon School of Engineering, L'Agence Francaise de Developpement (AFD), and Expertise France chose seven projects to receive the #Data4COVID19 Africa Challenge. -
'The Futures of Feminism', a new book by Professor Emerita Valerie Bryson
(University of Huddersfield) An inspirational panel of experts came together via an online event to celebrate the launch of Professor Bryson's new book which makes the case for an inclusive form of socialist feminism that puts women with multiple disadvantages at its heart -
Testing a new way to tackle cancer
(Michigan State University) A potential new weapon against cancer is entering the first phase of clinical trials.Michigan State University's Kurt Zinn, a professor of biomedical engineering, radiology and small animal clinical sciences, is leading the effort to validate an innovative radiotherapy as part of a safe, more effective and potentially less costly treatment for bladder cancer. -
Tattoo made of gold nanoparticles revolutionizes medical diagnostics
(Johannes Gutenberg Universitaet Mainz) Scientists have developed a novel type of implantable sensor that continuously transmits information on vital values and concentrations of substances or drugs in the body and can be operated in the body for several months. The sensor is based on color-stable gold nanoparticles that are modified with receptors for specific molecules. -
SwRI's 100-kg small satellite platform added to NASA's RDSO catalog
(Southwest Research Institute) NASA has selected Southwest Research Institute's 100 kg-class small satellite (SmallSat) platform to be listed in the Rapid Spacecraft Development Office (RSDO) IV catalog used by the U.S. government to rapidly contract for flight-proven spacecraft. The Southwest Space Platform-100 (SwSP-100) is now available through the $6 billion, indefinite delivery/indefinite quantity (IDIQ) Rapid Spacecraft Acquisition IV contract. -
SwRI receives up to $99 million to sustain aging Air Force aircraft
(Southwest Research Institute) Southwest Research Institute will study the effects of aging on military aircraft through a contract worth up to $99 million with the United States Air Force. This Indefinite Delivery Indefinite Quantity contract award supports the U.S. Air Force Academy Center for Aircraft Structural Life Extension (CAStLE), an Air Force program to address aging aircraft structures and material degradation. IDIQs are contract vehicles that fund work tasks over specified periods of -
Study links prenatal phthalate exposure to altered information processing in infants
(University of Illinois at Urbana-Champaign, News Bureau) Exposure to phthalates, a class of chemicals widely used in packaging and consumer products, is known to interfere with normal hormone function and development. Now researchers have found evidence linking pregnant women's exposure to phthalates to altered cognitive outcomes in their infants. -
Study finds risk of leukemia higher than expected in children with Down syndrome
(University of California - Davis Health) The risk of childhood leukemia among kids with Down syndrome is higher than predicted, according to a new study led by UC Davis and UC San Francisco researchers. Early diagnosis of leukemia remains critical. -
Spin defects under control
(University of Würzburg) An international research team has made progress towards improved materials for quantum sensor technology. Medicine, navigation and IT could benefit from this in the future. -
Small cell lung cancer: Scientists identify two new approaches for therapy
(University of Cologne) Iron-dependent cell death ferroptosis and cell death by oxidative stress can be activated in small cell lung cancer, and induced by two drugs / publication in 'Nature Communications' -
Silencing vibrations in the ground and sounds underwater
(Pohang University of Science & Technology (POSTECH)) POSTECH professor Junsuk Rho's research team demonstrates artificial control of elastic waves and underwater sounds applicable as stealth technology. -
Sharing and enjoying meals with loved ones reduces obesity and improves the health of adolescents
(Universitat Oberta de Catalunya (UOC)) Eating together as a family, maintaining the Mediterranean diet's traditional customs of conviviality, influences the eating habits of adolescents and prevents eating behaviour disorders, according to a new study prepared by scientists from the Universitat Oberta de Catalunya (UOC). -
Seismic coda used to locate and define damage from explosions
(Seismological Society of America) Comparison of coda waves, the scattered waves that arrive after the direct waves of a seismic event, can be used to determine the relative locations of two underground explosions, according to a new study published in the open-access journal The Seismic Record. -
Secure type: consumers say compact logos signal product safety
(Boston College) There are distinct design features organizations can incorporate into their logos in order to generate positive consumer responses about product safety, according to a new report in the Journal of Consumer Research by researchers at Boston College and the Indian Institute of Management Udaipur.
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